Carbamic acid, N-(3-iodophenyl)-, 1,1-dimethylethyl ester - Names and Identifiers
Carbamic acid, N-(3-iodophenyl)-, 1,1-dimethylethyl ester - Physico-chemical Properties
Molecular Formula | C11H14INO2
|
Molar Mass | 319.14 |
Density | 1.591±0.06 g/cm3(Predicted) |
Melting Point | 71-75°C |
Boling Point | 303.5±25.0 °C(Predicted) |
Solubility | Dichloromethane, Ethyl Acetate |
Appearance | Oil |
Color | Yellow |
pKa | 13.30±0.70(Predicted) |
Storage Condition | Room Temprature |
Carbamic acid, N-(3-iodophenyl)-, 1,1-dimethylethyl ester - Risk and Safety
Risk Codes | R22 - Harmful if swallowed
R43 - May cause sensitization by skin contact
R50 - Very Toxic to aquatic organisms
|
Safety Description | S36/37 - Wear suitable protective clothing and gloves.
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
|
UN IDs | UN 3077 9 / PGIII |
WGK Germany | 3 |
Carbamic acid, N-(3-iodophenyl)-, 1,1-dimethylethyl ester - Introduction
(3-iodo-phenyl)-CARBAMIC ACID TERT-BUTYL ESTER is an organic compound, its properties, uses, preparation methods and safety information are as follows:
Nature:
(3-IODO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is a white to light yellow solid that is flammable. It is stable at room temperature, but it is easy to decompose under high temperature, high pressure or light conditions. The compound is soluble in the solvent, but has a low solubility in water.
Use:
(3-IODO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is widely used in the field of organic synthesis. It is commonly used as a protecting group for aromatic amines. By protecting the nitrogen atom on the amine group, the activity and selectivity of the amine group can be protected during the chemical reaction. In addition, it is used in the preparation of intermediates and pharmaceuticals in organic synthesis.
Method:
(3-iodo-phenyl)-CARBAMIC ACID TERT-BUTYL ESTER is usually prepared by 3-iodoaniline as raw material through nuclear alkylation reaction and Boc ACID chloride reaction. The specific procedure involves the slow addition of the Boc acid chloride in a suitable solvent, followed by the addition of a base to neutralize the resulting HCl solution, and finally purification by crystallization to give the product.
Safety Information:
When using (3-IODO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER, care should be taken to prevent contact with skin, eyes and administration. It is irritating and allergenic and may pose a health hazard. Personal protective equipment should be worn during operation, including laboratory coats, gloves and safety glasses. At the same time, good ventilation conditions should be ensured during operation, and fire sources and high temperature environments should be avoided. In case of inhalation, skin contact or eye contact, rinse immediately with water and seek medical help.
Last Update:2024-04-09 21:11:58